Publications

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
Canver MC*, Smith EC*, Sher F*, Pinello L*, Sanjana NE*, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE. Nature2015 Nov

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell. 2015 Jul

Systematic dissection of the sequence determinants of gene 3’ end mediated expression control.
Shalem O*, Sharon E*, Lubliner S, Regev I, Lotan-Pompan M, Yakhini Z and Segal E. PLoS Genet. 2015 Apr

High-throughput functional genomics using CRISPR-Cas9.
Shalem O‡, Sanjana NE and Zhang F‡. Nature Rev Genet. 2015 Apr (‡ corresponding authors)

In vivo genome editing using Staphylococcus aureus Cas9.
Ran FA*, Cong L*, Yan WX*, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. Nature 2015 Apr

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.
Chen S*, Sanjana NE*, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Cell 2015 Mar

Improved lentiviral vectors and genome-wide libraries for genetic screening in human and mouse cells using the CRISPR nuclease Cas9.
Sanjana NE*, Shalem O* and Zhang F. Nature Methods. 2014 Aug

Genome-scale CRISPR-Cas9 knockout screening in human cells.
Shalem O*, Sanjana NE*, Hartenian E, Shi X, Scott DA, Mikkelsen TS, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Science 2014 Jan (Science research highlightsNature research highlightsNature Genetics research highlightsNature Methods research highlights)

DNA targeting specificity of RNA-guided Cas9 nucleases.
Hsu PD*, Scott DA*, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F. Nat Biotechnol. 2013 Sep

Measurements of the impact of 3′ end sequences on gene expression reveal wide range and sequence dependent effects.
Shalem O, Carey L, Zeevi D, Sharon E, Keren L, Weinberger A, Dahan O, Pilpel Y, Segal E. PLoS Comput Biol. 2013

Widespread promoter-mediated coordination of transcription and mRNA degradation.
Dori-Bachash M*, Shalem O*, Manor YS, Pilpel Y, Tirosh I. Genome Biol. 2012 Dec

Axonal transcription factors signal retrogradely in lesioned peripheral nerve.
Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, Yudin D, Rishal I, Rother F, Bader M, Blesch A, Pilpel Y, Twiss JL, Fainzilber M. EMBO J 2012 Mar

Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II.
Shalem O, Groisman B, Choder M, Dahan O, Pilpel Y. PLoS Genet. 2011 Sep

Signaling to transcription networks in the neuronal retrograde injury response.
Michaelevski I, Segal-Ruder Y, Rozenbaum M, Medzihradszky KF, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan SY, Rishal I, Geschwind DH, Pilpel Y, Burlingame AL, Fainzilber M.
Science Signal. 2010 Jul 13

Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.
Shalem O, Dahan O, Levo M, Martinez MR, Furman I, Segal E, Pilpel Y. Mol Syst Biol. 2008 (F1000 review)

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s